منابع مشابه
Parahippocampal volume deficits in subjects with aging-associated cognitive decline.
OBJECTIVE Neuropathological evidence suggests that the earliest changes in Alzheimer's disease selectively affect the parahippocampal regions of the brain. This study was conducted to determine if otherwise healthy elderly subjects with mild cognitive impairment had structural volume deficits affecting the parahippocampal gyrus. METHOD Magnetic resonance imaging (MRI) was used to compare glob...
متن کاملModels of the Aging Brain Structure and Individual Decline
The aging brain's structural development constitutes a spatiotemporal process that is accessible by MR-based computational morphometry. Here we introduce basic concepts and analytical approaches to quantify age-related differences and changes in neuroanatomical images of the human brain. The presented models first address the estimation of age trajectories, then we consider inter-individual var...
متن کاملBrain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve.
OBJECTIVES To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD). DESIGN Cross-sectional and longitudinal observation. SETTING Alzheimer's Disease Research Center, St Louis, Missouri. PARTICIPANTS Volunteer sample of 362 nondemented adults aged 18 to 93 yea...
متن کاملA longitudinal study of brain volume changes in normal aging.
PURPOSE To evaluate the effect of normal aging on brain volumes and examine the effects of age and sex on the rates of changes in global and regional brain volumes. METHODS A total of 199 normal subjects (65 females and 134 males, mean age=56.4 ± 9.9 years, age range=38.1-82.9 years) were included in this study. Each subject was scanned twice, at an interval of about 2 years (range=1.5-2.3 ye...
متن کاملAerobic exercise training increases brain volume in aging humans.
BACKGROUND The present study examined whether aerobic fitness training of older humans can increase brain volume in regions associated with age-related decline in both brain structure and cognition. METHODS Fifty-nine healthy but sedentary community-dwelling volunteers, aged 60-79 years, participated in the 6-month randomized clinical trial. Half of the older adults served in the aerobic trai...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2008
ISSN: 0003-9942
DOI: 10.1001/archneurol.2007.27